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jectReportProtocolRegisteredReportReplyRetractionShortNoteStudyProtocolSystematicReviewTechnicalNoteTutorialViewpoint  AdvancedSearch SectionSpecialIssueVolumeIssueNumberPe LogicalOperatorOperatorANDORSearchTextSearchTypeAllfieldsTitleAbstractKeywordsAuthorsAffiliationsDoiFullTextReferences add_circle_outlineremove_circle_outline  //SustainabilityFormation,Characteristics,andInfluencingFactorsofthePlastisphereSensorsHardSyDR:ABenchmarkingEnvironmentforGNSSAlgorithmsMicromachinesAReviewonMachiningSiCp/AlCompositeMaterialsCancersTheRoleofMacrophesinSarcomaTumorMicroenvironmentandTreatmentRecentArticles 27pes,2732KiB OpenAccessReviewPatentMiningontheUseofAntioxidantPhytochemicalsintheTechnologicalDevelopmentforthePreventionandTreatmentofPeriodontitisbyPauloJoséLimaJuiz,LuizaTelesBarbalhoFerreira,EdilsonAraújoPiresandCristianeFloraVillarrealAntioxidants2024,13(5),566;doi.org/10.3390/antiox(registering DOI)-03May2024AbstractPeriodontaldiseaseisaninflammatoryconditioncharacterizedbyanaberrantimmuneresponseainstadysbioticdentalbiofilm,withoxidativestressperforminganessentialroleinitspathogenesis.Thispaperpresentsapatentmining,performedintheOrbitIntelligencepatentdatabase,relatedtoantioxidant[...]Readmore.Periodontaldiseaseisaninflammatoryconditioncharacterizedbyanaberrantimmuneresponseainstadysbioticdentalbiofilm,withoxidativestressperforminganessentialroleinitspathogenesis.Thispaperpresentsapatentmining,performedintheOrbitIntelligencepatentdatabase,relatedtoantioxidantphytochemicalsinthetechnologicaldevelopmentsthatareworkingtopreventandtreatperiodontaldisease.Toaccessthedocuments,thedescriptors“PERIODONTAL”and“ANTIOXIDANT”weretypedinthetitle,abstract,andclaimsearchfields.Atotalof322patentsdemonstratethegrowinginterestinresearchingnaturalantioxidantsforscientificandtechnologicalpurposes.ThetoptencountriesregardingthenumberoffamilypatentsproducedweretheUnitedStates,theEuropeanOffice,Japan,SouthKorea,China,India,Mexico,Denmark,Canada,andGreatBritain.ThemostcitedcompoundswerevitaminC,greentea,quercetin,melatonin,lycopene,resveratrol,andcurcumin.Thesecompoundshebeenusedforthetechnologicaldevelopmentofgels,membranes,dentifrices,chewinggum,orallydisintegratingfilm,mouthwash,mouthspray,andmouthmassecreamandexhibittheabilitytoneutralizefreeradicalsandreduceoxidativestress,acriticalfactorinthedevelopmentandprogressionofperiodontaldiseases.Thepatentdocumentsheshownthatusingantioxidantcompoundsinconjunctionwithtraditionalperiodontaltreatmentsisapromisingareaofinterestinperiodontaltherapy.Fullarticle(ThisarticlebelongstotheSpecialIssuePharmacologicalPropertiesofNaturalAntioxidants)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,389KiB)17pes,3153KiB OpenAccessArticleEffectsofUV/H2O2DegradationonthePhysicochemicalandAntibacterialPropertiesofFucoidanbyZhichengHe,BiyangZhu,LijuanDengandLijunYouMar.Drugs2024,22(5),209;doi.org/10.3390/md-03May2024AbstractTheapplicationsoffucoidaninthefoodindustrywerelimitedduetoitshighmolecularweightandlowsolubility.Moderatedegradationwasrequiredtodepolymerizefucoidan.Afewstudieshereportedthatfucoidanhaspotentialantibacterialactivity,butitsantibacterialmechanismneedsfurther[...]Readmore.Theapplicationsoffucoidaninthefoodindustrywerelimitedduetoitshighmolecularweightandlowsolubility.Moderatedegradationwasrequiredtodepolymerizefucoidan.Afewstudieshereportedthatfucoidanhaspotentialantibacterialactivity,butitsantibacterialmechanismneedsfurtherinvestigation.Inthisstudy,thedegradedfucoidanswereobtainedafterultriolet/hydrogenperoxidetreatment(UV/H2O2)atdifferenttimes.TheirphysicochemicalpropertiesandantibacterialactivitiesainstStaphylococcusaureusandEscherichiacoliwereinvestigated.Theresultsshowedthattheeremolecularweightsofdegradedfucoidansweresignificantlydecreased(upto22.04times).Theyweremainlycomposedoffucose,galactose,andsomeglucuronicacid.Fucoidandegradedfor90min(DFuc-90)showedthestrongestantibacterialactivitiesainstStaphylococcusaureusandEscherichiacoli,withinhibitionzonesof27.70+0.84mmand9.25+0.61mm,respectively.Theminimuminhibitoryconcentrations(MIC)were8mg/mLand4mg/mL,respectively.DFuc-90couldinhibitthebacteriabydamingthecellwall,accumulatingintracellularreactiveoxygenspecies,reducingadenosinetriphosphatesynthesis,andinhibitingbacterialmetabolicactivity.Therefore,UV/H2O2treatmentcouldeffectivelydegradefucoidanandenhanceitsantibacterialactivity.Fullarticle(ThisarticlebelongstotheSpecialIssueBioactivePolysaccharidesfromSeaweeds)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure8Cont.21pes,585KiB OpenAccessArticleEnhancedMovingSourceLocalizationwithTimeandFrequencyDifferenceofArrival:Motion-AssistedMethodforSub-DimensionalSensorNetworksbyXuYangAppl.Sci.2024,14(9),3909;doi.org/10.3390/app(registering DOI)-03May2024AbstractLocalizingamovingsourcebyTimeDifferenceofArrival(TDOA)andFrequencyDifferenceofArrival(FDOA)commonlyrequiresatleastN+1sensorsinN-dimensionalspacetoobtainmorethanNpairsofTDOAsandFDOAs,therebyestablishingmorethan[...]Readmore.LocalizingamovingsourcebyTimeDifferenceofArrival(TDOA)andFrequencyDifferenceofArrival(FDOA)commonlyrequiresatleastN+1sensorsinN-dimensionalspacetoobtainmorethanNpairsofTDOAsandFDOAs,therebyestablishingmorethan2Nequationstosolvefor2Nunknowns.However,ifthereareinsufficientsensors,thelocalizationproblemwillbecomeunderdetermined,leadingtonon-uniquesolutionsorinaccuraciesintheminimumnormsolution.ThispaperproposesalocalizationmethodusingTDOAsandFDOAswhileincorporatingthemotionmodel.Themotionbetweenthesourceandsensorsincreasestheequivalentlengthofthebaseline,therebyimprovingobservabilityevenwhenusingtheminimumnumberofsensors.TheproblemisformulatedasaMaximumLikelihoodEstimation(MLE)andsolvedthroughGauss–Newton(GN)iteration.SinceGNrequiresaninitializationclosetothetruevalue,theMLEistransformedintoasemidefiniteprogrammingproblemusingSemidefiniteRelaxation(SDR)technology,whileSDRresultsinasuboptimalestimate,itissufficientasaninitializationtoguaranteetheconvergenceofGNiteration.TheproposedmethodisanalyticallyshowntoreachtheCramér–RaoLowerBound(CRLB)accuracyundermildnoiseconditions.SimulationresultsconfirmthatitachievesCRLB-levelperformancewhenthenumberofsensorsislowerthanN+1,therebycorroboratingthetheoreticalanalysis.Fullarticle(ThisarticlebelongstotheSpecialIssueRecentProgressinRadarTargetDetectionandLocalization)28pes,1837KiB OpenAccessArticleEmpoweringSustainability:UnderstandingDeterminantsofConsumerInvestmentinMicrogridTechnologyintheUAEbyHussainAbdallaSajwani,BasselSoudanandAbdulGhaniOlabiEnergies2024,17(9),2201;doi.org/10.3390/en(registering DOI)-03May2024AbstractThisstudyaimstoanalyzethedeterminantsthatinfluencetheconsumers’dispositiontoinvestinmicrogridtechnologyintheUnitedArabEmirates(UAE).Thisresearchoffersvaluableinsightsforpolicymakersoninvestors’motivationstodevelopstrategiestofostermicrogridtechnologyadoptionthroughend-user[...]Readmore.Thisstudyaimstoanalyzethedeterminantsthatinfluencetheconsumers’dispositiontoinvestinmicrogridtechnologyintheUnitedArabEmirates(UAE).Thisresearchoffersvaluableinsightsforpolicymakersoninvestors’motivationstodevelopstrategiestofostermicrogridtechnologyadoptionthroughend-userinvestmentsleadingtoareductioninmicrogridhighcapitalcost.Thestudyemployeddescriptivestatistics,correlation,andregressionanalysestoanalyzetheresponsesofasampleofpropertyownerstoaquantitativesurvey.Thestudyexaminessuchvariablesasstrategicalignment,profitability,digitization,renewableenergyutilization,CO2emissionreduction,anddisasterrecoveryreadiness.Thedatacollectedrevealamoderatelevelofunderstandingandcost-awarenessofmicrogridtechnologyamongtherespondents,withameanof2.46outof5.Notably,thedatahighlightthesignificantinfluenceofstrategicalignmentwiththeUAE’snationalenergygoalsontherespondents’inclinationtoinvestinmicrogrids,withastrongpositivecorrelationof0.942atthe0.01level(two-tailed).Bycomparison,profitabilityanddisasterrecoveryheacomparativelyweakercorrelation.Furthermore,basedonthedatacollectedduringthisstudy,ithasbeendeterminedthatthereisastrongvalueaddedbythemicrogridinitiativesconsideringtheUAE’sstrategicdirectionandthepositiveinfluenceofreducedCO2.TheregressionmodelsusedwerehighlysignificantatF=85.690.ThereisanacceptablelevelofmulticollinearitywithVIFvaluesrangingfrom1.087to2.155.UAEStrategyhaslowcollinearity.UAEStrategyemergesastheonlysignificantpredictorofwillingnesstoinvest(p<0.001)inthestepwiseregressionanalysis.TheanalysisshowsthatvillaandtownhouseownersarewillingtoinvestincommunitymicrogridgiventhatitisalignedwithUAEstrategyandleadstoCO2emissionsreduction.Fullarticle(ThisarticlebelongstotheTopicSustainableEnergy:EfficientTechnologicalSolutionsCombiningEnvironmental,Economic,PoliticalandSocialAspects)20pes,686KiB OpenAccessArticleProbingthePropellerRegimewithSymbioticX-rayBinariesbyMarinaD.AfoninaandSergeiB.PopovUniverse2024,10(5),205;doi.org/10.3390/universe(registering DOI)-03May2024AbstractAtthemoment,therearetwoneutronstarX-raybinarieswithmassiveredsupergiantsasdonors.Recently,Deetal.(2023)proposedthatthesystemSWIFTJ0850.8-4219containsaneutronstaratthepropellerste.Westudythispossibilitybyapplyingvariousmodels[...]Readmore.Atthemoment,therearetwoneutronstarX-raybinarieswithmassiveredsupergiantsasdonors.Recently,Deetal.(2023)proposedthatthesystemSWIFTJ0850.8-4219containsaneutronstaratthepropellerste.Westudythispossibilitybyapplyingvariousmodelsofpropellerspin-down.Wedemonstratethatthedurationofthepropellersteisverysensitivetotheregimeofrotationallosses.OnlyinthecaseofarelativelyslowpropellermodelproposedbyDiesandPringlein1981,thedurationofthepropellerislongenoughtoprovideasignificantprobabilitytoobservethesystematthisste.Futuredeterminationofthesystemparameters(orbitalandspinperiods,mneticfieldofthecompactobject,etc.)willallowputtingstrongconstraintsonthepropellerbehior.Fullarticle(ThisarticlebelongstotheSpecialIssueUniverse:FeaturePapers2024–CompactObjects)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure515pes,1811KiB OpenAccessArticleTheEffectofSustainableDevelopmentGoalsandSubjectingWell-BeingonArtNascentEntrepreneurship:TheModeratingRoleofEntrepreneurshipEducationbyStroulaLaspita,IoannisSitaridisandKaterinaSarriEduc.Sci.2024,14(5),491;doi.org/10.3390/educsci(registering DOI)-03May2024AbstractThisstudyexplorestheimpactoftheperceivedwell-beingofstudents;thedegreetowhichtheyperceivethattheiruniversityenhances,facilitates,andsupportssixsustainabledevelopmentgoals(SDGs);andentrepreneurshipeducationonnascententrepreneurship.Movingbeyondmaineffects,ourresearchusesentrepreneurship[...]Readmore.Thisstudyexplorestheimpactoftheperceivedwell-beingofstudents;thedegreetowhichtheyperceivethattheiruniversityenhances,facilitates,andsupportssixsustainabledevelopmentgoals(SDGs);andentrepreneurshipeducationonnascententrepreneurship.Movingbeyondmaineffects,ourresearchusesentrepreneurshipeducationasamoderator,offeringnuancedinsightsintonascententrepreneurship,particularlyamongartstudents—anunder-researchedgroup.UtilizingdatafromalargesamplewithintheestablishedresearchprojectGUESSS,ourfindingsshowaverysmallstatisticallysignificantpositiverelationshipbetweensubjectivewell-beingandnascententrepreneurshipamongartstudents.However,theanticipatedimpactofuniversityenhancement,facilitation,andsupportofSDGsonnascententrepreneurshipisnotevidentforthesestudents.Notably,entrepreneurshipeducationisimportantforthecultivationofthefuturegenerationofartentrepreneurs.Theseresultsheimportanttheoreticalandpracticalimplications.Fullarticle(ThisarticlebelongstotheSpecialIssueEntrepreneurshipEducation:ChallengedandChallenging)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure520pes,1226KiB OpenAccessArticlePerceptionversusHistoricalKnowledgeinBaccalaureate:AComparativeStudyMediatedbyAugmentedRealityandHistoricalThinkingbyAlejandroLópez-García,JierJ.Maquilón-SánchezandPedroMiralles-SánchezAppl.Sci.2024,14(9),3910;doi.org/10.3390/app(registering DOI)-03May2024AbstractNumerousstudiesheshownthatatraditionalmodelpersistsintheteachingofhistory,inwhichstudentsarenotallowedtothinkforthemselvesandareassignedapassiverolebasedonthemerememorisationofinformation.Thisrealityisinoppositionto[...]Readmore.Numerousstudiesheshownthatatraditionalmodelpersistsintheteachingofhistory,inwhichstudentsarenotallowedtothinkforthemselvesandareassignedapassiverolebasedonthemerememorisationofinformation.Thisrealityisinoppositiontothetechnologicalandtechnicalboomtakingplaceinthecurrenteducationalcontextandtotheenhancementofinnovativestrategiesandmethodologiesthatmarktherolethatstudentsmustoccupyasprotonistsoftheirownlearning.Thispaperaimstocomparetheperceptionsandhistoricalknowledgeof93baccalaureatestudents(16–18yearsofe)followingtheimplementationofaninterventionprogrammebasedonactivelearningsituationsmediatedbyaugmentedrealityandhistoricalthinkingskills.Aquasi-experimentalquantitativedesignwithanon-equivalentcontrolgroupwasemployedtomeettheseobjectives.Theresultsshowedhigherscoresintheperceptionandknowledgeofstudentsintheexperimentalgroupcomparedwiththoseinthecontrolgroup.Thislineofworkshouldbecontinuedinthefuturewithnewstudiestocorroboratethesefindings,prioritisingpedogicalmodelsbasedonstudentactivityandprotonismviatheuseoftechnologyandcriticalthinking.Fullarticle(ThisarticlebelongstotheSpecialIssueArtificialIntelligenceandInformationVisualizationinSocialandIndustrialSystems)14pes,703KiB OpenAccessArticleMicrostructuralandHydrophilicPropertiesofPolylactidePolymerSampleswithVarious3DPrintingPatternsbyAlexandrS.Lenshin,VeraE.Frolova,SergeyV.KannykinandEvelinaP.DomashevskayaPolymers2024,16(9),1281;doi.org/10.3390/polym(registering DOI)-03May2024AbstractTheaimoftheworkistostudytheeffectofthe3Dprintingprocessonthemicrostructuralandhydrophilicpropertiesofpolylacticacid(PLA)sampleswithvariousmodelprintingpatternsobtainedfromtheblackfilamentPLAbysequentiallyapplyingpolymerlayersusing[...]Readmore.Theaimoftheworkistostudytheeffectofthe3Dprintingprocessonthemicrostructuralandhydrophilicpropertiesofpolylacticacid(PLA)sampleswithvariousmodelprintingpatternsobtainedfromtheblackfilamentPLAbysequentiallyapplyingpolymerlayersusingtheFDM(fuseddepositionmodeling)method.X-rayphaseanalysisrevealedthepartialcrystallizationofPLApolymerchainsintheprintedsamples,whichoccursunderthermalandmechanicalactionontheoriginalamorphousPLAfilamentduring3Dprintingtovaryingdegrees,dependingonthegeometryofthepatternandthemorphologyofitssurface.Atthesametime,IRspectroscopydataindicatethepreservationofallintrastructuralchemicalbondsofpolylactide.Measuredattheoriginalinstallation,thevaluesofthewettingedgeanglesonthesurfaceoftheprintedsamplesareintherangeφ=50–60°,whichissignificantlylessthantherightangle.Thisindicatesthehydrophilicpropertiesofthewholesample’ssurface.Atthesametime,theinfluenceofdifferentgeometriesofmodeldrawingsinprintedsampleswasfoundnotonlyonthemorphologyofthesample’ssurfaceaccordingtoSEMdatabutalsoonitswettability.Fullarticle(ThisarticlebelongstotheSectionPolymerAnalysisandCharacterization)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,314KiB)14pes,1006KiB OpenAccessFeaturePaperArticleMeropenemDispositioninNeonatalandPediatricExtracorporealMembraneOxygenationandContinuousRenalReplacementTherapybyPlaPokorná,DanicaMichaličková,DickTibboelandJonasBernerAntibiotics2024,13(5),419;doi.org/10.3390/antibiotics(registering DOI)-03May2024AbstractThisstudyaimedtocharacterizetheimpactofextracorporealmembraneoxygenation(ECMO)onthepharmacokinetics(PK)ofmeropeneminneonatesandchildrenandtoproviderecommendationsformeropenemdosinginthisspecificpopulationofpatients.Therapeuticdrugmonitoring(152meropenemplasmaconcentrations)data[...]Readmore.Thisstudyaimedtocharacterizetheimpactofextracorporealmembraneoxygenation(ECMO)onthepharmacokinetics(PK)ofmeropeneminneonatesandchildrenandtoproviderecommendationsformeropenemdosinginthisspecificpopulationofpatients.Therapeuticdrugmonitoring(152meropenemplasmaconcentrations)datafrom45patients(38receivedECMO)withabodyweight(BW)of7.88(3.62–11.97)kg(median(interquartilerange))andpostnataleof3(0–465)dayswerecollected.ThepopulationPKanalysiswasperformedusingNONMEMV7.3.0.MonteCarlosimulationswereperformedtoassesstheprobabilityoftargetachievement(PTA)for40%oftimethefreedrugremainedabovetheminimuminhibitoryconcentration(fT>MIC)and100%fT>MIC.BWwasfoundtobeasignificantcovariateforthevolumeofdistribution(Vd)andclearance(CL).Additionally,continuousrenalreplacementtherapy(CRRT)wasassociatedwithatwo-foldincreaseinVd.Inthefinalmodel,theCLandVdforatypicalpatientwithamedianBWof7.88kgthatwasoffCRRTwere1.09L/h(RSE=8%)and3.98L(14%),respectively.ECMOdidnotaffectmeropenemPK,whilesuperimposedCRRTsignificantlyincreasedVd.WeconcludedthatcurrentdosingregimensprovideacceptablyhighPTAforMIC≤4mg/Lfor40%fT>MIC,butindividualdoseadjustmentsareneededfor100%fT>MIC.Fullarticle(ThisarticlebelongstotheSpecialIssuePharmacokineticandAntibioticDosingforIntensiveCareUnitPatients)9658;9660;ShowFiguresFigure1attachmeTolong tunggu... AwanntSupplementarymaterial:SupplementaryFile1(ZIP,12KiB)16pes,6195KiB OpenAccessArticleLevosimendanandDobutaminAttenuateLPS-InducedInflammationinMicrogliabyInhibitingtheNF-κBPathwayandNLRP3InflammasomeActivationviaNrf2/HO-1SignallingbyFedericaMannino,ValentinaUrzìBrancati,RitaLauro,IgorPirrotta,MichelangeloRottura,NatashaIrrera,GianMariaCallini,GiovanniPallio,EloisaGittoandSaraMantiBiomedicines2024,12(5),1009;doi.org/10.3390/biomedicines(registering DOI)-03May2024AbstractHypovolemicshockisacirculatoryfailure,duetoalossintheeffectivecirculatingbloodvolume,thatcausestissuehypoperfusionandhypoxia.Thisconditionstimulatesreactiveoxygenspecies(ROS)andpro-inflammatorycytokineproductionindifferentorgansandalsointhecentralnervoussystem[...]Readmore.Hypovolemicshockisacirculatoryfailure,duetoalossintheeffectivecirculatingbloodvolume,thatcausestissuehypoperfusionandhypoxia.Thisconditionstimulatesreactiveoxygenspecies(ROS)andpro-inflammatorycytokineproductionindifferentorgansandalsointhecentralnervoussystem(CNS).Levosimendan,acardioprotectiveinodilator,anddobutamine,aβ1-adrenergiconist,arecommonlyusedforthetreatmentofhypovolemicshock,thankstotheiranti-inflammatoryandantioxidanteffects.Forthisreason,weaimedatinvestigatinglevosimendananddobutamine’sneuroprotectiveeffectsinan“invitro”modeloflipopolysaccharide(LPS)-inducedneuroinflammation.Humanmicroglialcells(HMC3)werechallengedwithLPS(0.1µg/mL)toinduceaninflammatoryphenotypeandthentreatedwithlevosimendan(10µM)ordobutamine(50µM)for24h.LevosimendananddobutaminesignificantlyreducedtheROSlevelsandmarkedlyincreasedNrf2andHO-1proteinexpressioninLPS-challengedcells.Levosimendananddobutaminealsodecreasedp-NF-κBexpressionandturnedofftheNLRP3inflammasometogetherwithitsdownstreamsignals,caspase-1andIL-1β.Moreover,areductioninTNF-αandIL-6expressionandanincreaseinIL-10levelsinLPS-stimulatedHMC3cellswasobservedfollowingtreatment.Inconclusion,levosimendananddobutamineattenuatedLPS-inducedneuroinflammationthroughNF-κBpathwayinhibitionandNLRP3inflammasomeactivationviaNrf2/HO-1signalling,suggestingthatthesedrugscouldrepresentapromisingtherapeuticapproachforthetreatmentofneuroinflammationconsequenttohypovolemicshock.Fullarticle(ThisarticlebelongstotheSpecialIssueNeuroinflammation:FromPathophysiologicMechanismstoTherapeuticStrategies)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure9attachmentSupplementarymaterial:SupplementaryFile1(ZIP,9189KiB)19pes,3995KiB OpenAccessArticleMicrobialPolysaccharidesExtractedfromDifferentMatureMudsoftheEuganeanThermalDistrictShowSimilarAnti-InflammatoryActivityInVivobyMicolCaichiolo,RaffaellaMargheritaZampieri,AlessandraAdessi,MatildeCiani,FabrizioCaldara,LuisaDallaValleandNicolettaLaRoccaInt.J.Mol.Sci.2024,25(9),4999;doi.org/10.3390/ijms(registering DOI)-03May2024AbstractTheEuganeanThermalDistrict,situatedinNorth-EastItaly,isoneofEurope’slargestandoldestthermalcentres.ThetopicalapplicationofitstherapeuticthermalmudsisrecognisedbytheItalianHealthSystemasabeneficialtreatmentforpatientssufferingfromarthro-rheumaticdiseases.Polysaccharides[...]Readmore.TheEuganeanThermalDistrict,situatedinNorth-EastItaly,isoneofEurope’slargestandoldestthermalcentres.ThetopicalapplicationofitstherapeuticthermalmudsisrecognisedbytheItalianHealthSystemasabeneficialtreatmentforpatientssufferingfromarthro-rheumaticdiseases.Polysaccharidesproducedbythemudmicrobiotahebeenrecentlyidentifiedasanti-inflammatorybioactivemolecules.InthispaperweanalysedtheefficacyofMicrobial-Polysaccharides(M-PS)derivedfrommaturemudsobtainedatdifferentmaturationtemperatures,bothwithinandoutsidethecodifiedtraditionalmudmaturationrange.M-PSswereextractedfromsixmaturemudsproducedbyfivespasoftheEuganeanThermalDistrictandinvestigatedfortheirchemicalproperties,monosaccharidecompositionandinvivoanti-inflammatorypotential,usingthezebrafishmodelorganism.Additionally,maturemudswerecharacterizedfortheirmicrobiotacompositionusingNext-GenerationSequencing.TheresultsshowedthatallM-PSsexhibitsimilaranti-inflammatorypotential,referabletotheircomparablechemicalcomposition.Thisconsistencywasobserveddespitechangesincyanobacteriapopulations,suggestingapossibleroleoftheentiremicrobialcommunityinshapingthepropertiesofthesebiomolecules.ThesefindingshighlighttheimportanceofscientificresearchinuntanglingtheoriginsofthetherapeuticefficacyofEuganeanThermalmudsinthetreatmentofchronicinflammatoryconditions.Fullarticle(ThisarticlebelongstotheSpecialIssueInvestigationofNaturalProductsasSourcesofBioactiveMolecules)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure812pes,5210KiB OpenAccessArticleManufacturingShape-ControllableFlexiblePEDOT/rGOCompositeElectrodesforPlanarMicro-SupercapacitorsbyHaiweiHu,YanyanGuoandJiangZhaoMaterials2024,17(9),2144;doi.org/10.3390/ma(registering DOI)-03May2024AbstractFlexibleelectronicproducts,withtheircharacteristicsofflexibilityandwearability,heattractedsignificantattentionandhebecomeanimportantdirectionintheresearchanddevelopmentoftheelectronicsindustry.Planarmicro-supercapacitors(MSCs)withflexiblecompositeelectrodescanprovidereliableenergysupportforthese[...]Readmore.Flexibleelectronicproducts,withtheircharacteristicsofflexibilityandwearability,heattractedsignificantattentionandhebecomeanimportantdirectionintheresearchanddevelopmentoftheelectronicsindustry.Planarmicro-supercapacitors(MSCs)withflexiblecompositeelectrodescanprovidereliableenergysupportfortheseproducts,propellingtheirfurtherdevelopment.Theresearchemployedaquick,effective,andenvironmentallyfriendlymethodoflaserscribingtocreateshape-controllableflexiblecompositeelectrodesoncompositefilmsofPoly(3,4-ethylenedioxythiophene)andgrapheneoxide(PEDOT/GO),whichweresubsequentlyassembledintoMSCs.Ananalysisofthecompositeelectrodemorphology,structure,andelementaldistributionwasconductedthroughtheutilizationofSEM,TEM,andXPStechniques.Followingthis,acomprehensiveevaluationoftheelectrochemicalperformanceoftheflexibleMSCswascarriedout,whichincludedcyclicvoltammetry(CV),galvanostaticcharge/discharge(GCD),andassessmentofcyclicstability.TheanalysisoftheCVresultsindicatedthattheMSCsachievedthearealcapacitanceof5.78mF/cm2at5mV/s.After5000cyclesatacurrentdensityof0.05mA/cm2,thecapacitanceretentionratewas85.4%.ThehigharealcapacitanceandstrongcyclestabilityofMSCshighlightthepotentialofPEDOT/reducedgrapheneoxide(PEDOT/rGO)electrodesinelectrodeapplications.Fullarticle(ThisarticlebelongstotheTopicElectrochemicalEnergyStoreMaterials)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure913pes,6366KiB OpenAccessArticleReconstructingKaoliniteCompoundsforRemarkablyEnhancedAdsorptionofCongoRedbyTingLiu,XinleLi,HaoWang,MingyangLi,HuaYang,YunhuiLiao,WufeiTang,YongLiandFangLiuMolecules2024,29(9),2121;doi.org/10.3390/molecules(registering DOI)-03May2024AbstractOrganicdyesarewidelyusedinmanyimportantareas,buttheyalsobringmanyissuesforwaterpollution.Toaddresstheaboveissues,areconstructedkaolinitehybridcompound(γ-AlOOH@A-Kaol)wasobtainedfromrawkaolinite(Kaol)inthiswork.Theproductwasthencharacterized[...]Readmore.Organicdyesarewidelyusedinmanyimportantareas,buttheyalsobringmanyissuesforwaterpollution.Toaddresstheaboveissues,areconstructedkaolinitehybridcompound(γ-AlOOH@A-Kaol)wasobtainedfromrawkaolinite(Kaol)inthiswork.TheproductwasthencharacterizedbyX-raydiffraction(XRD),Fourier-transforminfrared(ATR-FTIR),Brunauer-Emmett-Teller(BET),andscanningelectronmicroscopy(SEM),andtheabsorptionpropertiesofγ-AlOOH@A-Kaolforcongoredwerefurtherstudied.Theresultsdemonstratedthatflower-likeγ-AlOOHwithnanolamellaewereuniformlyloadedonthesurfaceofacid-treatedKaolwithaporousstructure(A-Kaol).Inaddition,thesurfacearea(36.5m2/g),porevolume(0.146cm3/g),andporesize(13.0nm)ofγ-AlOOH@A-KaolweredifferentfromthoseofA-Kaol(127.4m2/g,0.127cm3/g,and4.28nm,respectively)andγ-AlOOH(34.1m2/g,0.315cm3/g,and21.5nm,respectively).Theuniquestructurecouldsignificantlyenhancethesorptioncapacityforcongored,whichcouldexceed1000mg/g.Thereasonsmaybeascribedtotheabundantgroupsof-OH,largespecificsurfacearea,andporousstructureofγ-AlOOH@A-Kaol.ThisworkprovidesanefficientrouteforcomprehensiveutilizationandproductionofKaol-basedcompoundmaterialsthatcouldbeusedinthefieldofenvironmentalconservation.Fullarticle(ThisarticlebelongstotheSpecialIssueAdsorbentMaterialforWaterTreatment)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure9---Figure10---Figure11attachmentSupplementarymaterial:SupplementaryFile1(ZIP,165KiB)18pes,1774KiB OpenAccessArticleCoffeeExtractasaNaturalAntioxidantinFreshPorkSause—AModelApproachbyVanessaTanaraFetsch,DaneysaLahisKalschne,CristianeCanan,ÉderLisandrodeMoraesFlores,MarceloCaldeiraViegas,GabrielleCarolinePeiter,RicardoFioriZara,JoanaSoaresAmaralandMarinêsPaulaCorsoFoods2024,13(9),1409;doi.org/10.3390/foods(registering DOI)-03May2024AbstractConsumersareincreasinglylookingforhealthyfoodswithouttheadditionofsyntheticadditives.Theaimofthisstudywastoevaluatetheefficiencyofcoffeeextractsasanaturalantioxidantinfreshporksause.Firstly,theconditionsforobtainingcoffeegreenextractswere[...]Readmore.Consumersareincreasinglylookingforhealthyfoodswithouttheadditionofsyntheticadditives.Theaimofthisstudywastoevaluatetheefficiencyofcoffeeextractsasanaturalantioxidantinfreshporksause.Firstly,theconditionsforobtainingcoffeegreenextractswereoptimized(CentralCompositeRotatableDesign23,variables:extractiontime,ethanol–waterratio,andsample–solventratio)inanultrasoundbath(70°C).Theresponsevariableswerethebioactivecompoundslevelsandantioxidantactivity.Validmodelswereobtained(p≤0.05,R2>0.751),withhigherbioactivecontentandantioxidantactivityinthecentralpointregion.ExtractsofRobustaandArabicacoffeegreen(RGand)andmediumroast(RRandAR)obtained,andcentralpoint(10min,anethanolconcentrationof30%,andasample–solventratioof10g/100mL)andoptimized(14.2min,34.2%,and5.8g/100mL)parameterswerecharacterized.TheRGpresentedasignificantly(p≤0.05)highercontentofcaffeine(3114.8±50.0and3148.1±13.5mg/100g)and5-CQA(6417.1±22.0and6706.4±23.5mg/100g)inbothextractionconditions,respectively.TheRGandRRcoffeepresentedthehighestantioxidantactivity.TwoconcentrationsofRGandRRcoffeeextractsweretestedinfreshporksause.TheRobustacoffeeextractpresentedthehighestantioxidantactivityinbothroastedandgreenstates.However,whenappliedtoameatproduct,theextractpreparedwithRGcoffeeshowedbetterresults,withefficiencyinreplacingsyntheticantioxidants(contentofmalonaldehyde/kgofsamplebelow0.696±0.059in20daysofstore),withoutalteringthesensoryattributesoftheproduct(erescoresabove7.16±1.43forallattributesevaluated).Therefore,theRGcoffeeextractwasasuitablealternativeasanaturalantioxidantappliedtofreshporksause.Fullarticle(ThisarticlebelongstotheSpecialIssueNaturalBioactiveCompoundsfromFruitsandVegetables:ExtractionTechnologies,PhysicochemicalPropertiesandHealthBenefits)9658;9660;ShowFiguresGraphicalabstractFigure1---Figure2---Figure3attachmentSupplementarymaterial:SupplementaryFile1(ZIP,267KiB)11pes,1846KiB OpenAccessArticleRedox-ModifiedNanostructuredElectrochemicalSurfacesforContinuousGlucoseMonitoringinComplexBiologicalFluidsbySajjadJanfaza,NandhineeRadhaShanmugam,PawanJolly,PrashanthiKovur,UpasanaSingh,ScottMackay,DidWishartandDonaldE.IngberNanomaterials2024,14(9),796;doi.org/10.3390/nano(registering DOI)-03May2024AbstractContinuousglucosemonitoringisvaluableforpeoplewithdiabetesbutfaceslimitationsduetoenzyme–electrodeinteractionsandbiofoulingfrombiologicalsamplesthatreducesensorsensitivityandthemonitoringperformance.Wecreatedanenzyme-basedelectrochemicalsystemwithauniquenanocompositecoatingthatincorporatesthe[...]Readmore.Continuousglucosemonitoringisvaluableforpeoplewithdiabetesbutfaceslimitationsduetoenzyme–electrodeinteractionsandbiofoulingfrombiologicalsamplesthatreducesensorsensitivityandthemonitoringperformance.Wecreatedanenzyme-basedelectrochemicalsystemwithauniquenanocompositecoatingthatincorporatestheredoxmolecule,aminoferrocene(NH2-Fc).Thiscoatingenhancesstabilityviaelectroactivityandreducesnonspecificbinding,asdemonstratedthroughcyclicvoltammetry.Ourapproachenablesreal-timeglucosedetectionviachronoamperometrywithacalculatedlinearrangeof0.5to20mManda1mMdetectionlimit.Validatedwithplasmaandsaliva,thisplatformshowspromiseforrobustmetabolitedetectioninclinicalandresearchcontexts.Thisversatileplatformcanbeappliedtoaccuratelymonitorawiderangeofmetabolitesinvariousbiologicalmatrices,improvingpatientoutcomes.Fullarticle9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure517pes,646KiB OpenAccessArticleDeterminingEasternRedCedarBiocharSoilless-MediaSupplementationRatesforPottedGeraniumandPetuniaProductionbyBabitaLamichhane,BruceL.Dunn,HardeepSingh,AjayKumarandF.BaileyNorwoodHorticulturae2024,10(5),467;doi.org/10.3390/horticulturae(registering DOI)-03May2024AbstractTheuseofbiocharinsoillessmediaisbecomingmorecommoningreenhouseproduction.ThisstudywasconductedtoevaluateEasternredcedarbiocharasasoilless-mediasupplementforthegrowthofgeranium(PelargoniumgreolensL.)andpetunia(Petuniasp.J.)[...]Readmore.Theuseofbiocharinsoillessmediaisbecomingmorecommoningreenhouseproduction.ThisstudywasconductedtoevaluateEasternredcedarbiocharasasoilless-mediasupplementforthegrowthofgeranium(PelargoniumgreolensL.)andpetunia(Petuniasp.J.)aspottedplantsingreenhousese.Easternredcedarbiomasswasproducedatthreedifferenttemperatureranges300–350°C,400–450°C,and500–550°Candappliedat15%,30%,45%,and60%v/vtoasoillessmediaplusacontrol.Additionally,Easternredcedar(ERC)barkwasalsoappliedat15%,30%,45%,and60%v/vtoasoillessmedia.Thegrowthcharacteristicsoftheplantsalongwiththephysicalandnutrientpropertiesofthegrowthmediawererecorded.Forphysicalproperties,100%soillessmediahadthegreatestbulkdensity,60%biocharat400–450°Cshowedthegreatesttotalporosity,and60%ERCbarkshowedthegreatestairporosity.Forgeranium,15%biocharat500–550°Cshowedthegreatestheight,wateruseefficiency,andshootdryweight,while15%biocharat300–350°Cshowedthegreatestwidth.Thegreatestnumberofflowerswasat45%biocharat500–550°C.Forpetunia,15%biocharat300–350°Cshowedthegreatestheight,and15%biocharat500–550°Cshowedthegreatestwidth.Thegreatestnumberofflowersandflowerdiameterwasachievedwith100%soillessmedia.The15%biocharat500–550°Chadthegreatestshootdryweightandwateruseefficiency,and60%biocharat400–450°Chadthegreatestrootdryweight.BiochartreatmentoutperformstheERCbarktreatmentforbothspecies.Withinbiochartreatment,15%biocharoutperformsdrybiomass,whileforflowering,100%soillessmediaperformsbestforpetunia,andbiocharperformsbestatlessthan45%forgeranium.Fullarticle(ThisarticlebelongstotheSectionProtectedCulture)9658;9660;ShowFiguresFigure112pes,287KiB OpenAccessArticleExistenceResultsandFinite-TimeStabilityofaFractional(p,q)-Integro-DifferenceSystembyMouatazBillahMesmouli,LoredanaFlorentinaIambor,AmirAbdelMenaemandTaherS.HassanMathematics2024,12(9),1399;doi.org/10.3390/math(registering DOI)-03May2024AbstractInthisarticle,wemainlygeneralizetheresultsintheliteratureforafractionalq-differenceequation.Ourstudyconsidersamorecomprehensivetypeoffractionalp,q-differencesystemofnonlinearequations.BytheBanachcontractionmappingprinciple,weobtaina[...]Readmore.Inthisarticle,wemainlygeneralizetheresultsintheliteratureforafractionalq-differenceequation.Ourstudyconsidersamorecomprehensivetypeoffractionalp,q-differencesystemofnonlinearequations.BytheBanachcontractionmappingprinciple,weobtainauniquesolution.ByKrasnoselskii’sfixed-pointtheorem,weprovetheexistenceofsolutions.Inaddition,finitestabilityhasbeenestablishedtoo.Themainresultsintheliteraturehebeenproventobeaparticularcorollaryofourwork.Fullarticle(ThisarticlebelongstotheSpecialIssueRecentInvestigationsofDifferentialandFractionalEquationsandInclusions,3rdEdition)16pes,5286KiB OpenAccessArticleSaliency-GuidedPointCloudCompressionfor3DLiveReconstructionbyPietroRuiu,LorenzoMasciaandEnricoGrossoMultimodalTechnol.Interact.2024,8(5),36;doi.org/10.3390/mti(registering DOI)-03May2024Abstract3DmodelingandreconstructionarecriticaltocreatingimmersiveXRexperiences,providingrealisticvirtualenvironments,objects,andinteractionsthatincreaseuserengementandenablenewformsofcontentmanipulation.Today,3Ddatacanbeeasilycapturedusingoff-the-shelf,specializedheadsets;veryoften,these[...]Readmore.3DmodelingandreconstructionarecriticaltocreatingimmersiveXRexperiences,providingrealisticvirtualenvironments,objects,andinteractionsthatincreaseuserengementandenablenewformsofcontentmanipulation.Today,3Ddatacanbeeasilycapturedusingoff-the-shelf,specializedheadsets;veryoften,thesetoolsprovidereal-time,albeitlow-resolution,integrationofcontinuouslycaptureddepthmaps.ThisapproachisgenerallysuitableforbasicARandMRapplications,whereuserscaneasilydirecttheirattentiontopointsofinterestandbenefitfromafullyuser-centricperspective.However,itprovestobelesseffectiveinmorecomplexscenariossuchasmulti-usertelepresenceortelerobotics,wherereal-timetransmissionoflocalsurroundingstoremoteusersisessential.Twoprimaryquestionsemerge:(i)whatstrategiesareailableforachievingreal-time3Dreconstructioninsuchsystems?and(ii)howcantheeffectivenessofreal-time3Dreconstructionmethodsbeassessed?Thispaperexploresvariousapproachestothechallengeoflive3Dreconstructionfromtypicalpointclouddata.Itfirstintroducessomecommondataflowpatternsthatcharacterizevirtualrealityapplicationsandshowsthatachievinghigh-speeddatatransmissionandefficientdatacompressioniscriticaltomaintainingvisualcontinuityandensuringasatisfactoryuserexperience.Thepaperthusintroducestheconceptofsaliency-drivencompression/reconstructionandcomparesitwithalternativestate-of-the-artapproaches.Fullarticle9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure815pes,5279KiB OpenAccessArticleFunctionalizedChitosanandAlginateCompositeHydrogel-ImmobilizedLaccasewithSustainableBiocatalystsfortheEffectiveRemovalofOrganicPollutantBisphenolAbyHongZhang,XinZhang,LeiWang,BoWang,XuZengandBoRenCatalysts2024,14(5),304;doi.org/10.3390/catal(registering DOI)-03May2024AbstractTheimmobilizationofenzymesisanimportantstrategytoimprovetheirstabilityandreusability.Enzymeimmobilizationtechnologyhasbroadapplicationprospectsinbiotechnology,biochemistry,environmentalremediation,andotherfields.Inthisstudy,compositesofchitosan(CS)andsodiumalginate(SA)withCu2+[...]Readmore.Theimmobilizationofenzymesisanimportantstrategytoimprovetheirstabilityandreusability.Enzymeimmobilizationtechnologyhasbroadapplicationprospectsinbiotechnology,biochemistry,environmentalremediation,andotherfields.Inthisstudy,compositesofchitosan(CS)andsodiumalginate(SA)withCu2+formingadouble-networkcrosslinkedstructureofhydrogelswerepreparedandusedfortheimmobilizationoflaccase.Fourierinfraredspectroscopy,scanningelectronmicroscopy,andX-rayphotoelectronspectroscopytestsrevealedthatlaccasemoleculeswereimmobilizedonthecompositehydrogelsurfacebyacovalentbondingmethod.Comparedtofreelaccase,thepH,temperature,andstorestabilityoftheimmobilizedlaccaseweremarkedlyimproved.Inaddition,theimmobilizedlaccasecouldbeeasilyseparatedfromthereactionsystemandreused,anditmaintained81.6%ofitsinitialviabilityaftersixcyclesofuse.BisphenolA(BPA)inpollutedwaterwasefficientlydegradedusingimmobilizedlaccase,andthefactorsaffectingthedegradationefficiencywereanalyzed.Undertheoptimalconditions,theBPAremovalwasgreaterthan82%,andtheadditionofasmallamountofABTShadasignificanteffectonBPAdegradation,witharemovalrateofupto99.1%.Experimentalresultsindicatedthatimmobilizedlaccaseshadenormouspotentialinactualindustrialapplications.Fullarticle(ThisarticlebelongstotheSectionBiocatalysis)9658;9660;ShowFiguresGraphicalabstractFigure1---Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure920pes,1409KiB OpenAccessArticleComprehensiveAnalysisofCXCR4,JUNB,andPD-L1ExpressioninCirculatingTumorCells(CTCs)fromProstateCancerPatientsbyArgyroRoumeliotou,AretiStrati,FoteiniChamchougia,AnastasiaXara,VictoriaTserpeli,StroulaSmilkou,ElinaLopodi,AthinaChristopoulou,EmmanouilKontopodis,IoannisDrositis,NikolaosAndroulakis,VassilisGeorgoulias,FilipposKoinis,AthanasiosKotsakis,EviLianidouandGalateaKallergiCells2024,13(9),782;doi.org/10.3390/cells(registering DOI)-03May2024AbstractCXCR4,JUNBandPD-L1areimplicatedincancerprogressionandmetastasis.ThecurrentstudyinvestigatedthesebiomarkersinCTCsisolatedfrommetastaticprostatecancer(mPCa)patientsattheRNAandproteinlevels.CTCswereisolatedfrom48mPCapatientsusingtheFicolldensity[...]Readmore.CXCR4,JUNBandPD-L1areimplicatedincancerprogressionandmetastasis.ThecurrentstudyinvestigatedthesebiomarkersinCTCsisolatedfrommetastaticprostatecancer(mPCa)patientsattheRNAandproteinlevels.CTCswereisolatedfrom48mPCapatientsusingtheFicolldensitygradientandISETsystem(17outof48).The(CK/PD-L1/CD45)and(CK/CXCR4/JUNB)phenotypeswereidentifiedusingtwotripleimmunofluorescencestainingsfollowedbyVyCAPplatformanalysis.MolecularanalysiswasconductedwithanEpCAM-dependentmethodfor25/48patients.CK-8,CK-18,CK-19,JUNB,CXCR4,PD-L1,andB2M(referencegene)wereanalyzedwithRT-qPCR.The(CK+/PD-L1+/CD45–)andthe(CK+/CXCR4+/JUNB+)werethemostfrequentphenotypes(61.1%and62.5%,respectively).Furthermore,the(CK+/CXCR4+/JUNB–)phenotypewascorrelatedwithpoorerprogression-freesurvival[(PFS),HR:2.5,p=0.049],whilethe(CK+/PD-L1+/CD45–)phenotypewaslinkedtodecreasedoverallsurvival[(OS),HR:262.7,p=0.007].Molecularanalysisrevealedthat76.0%ofthesampleswerepositiveforCK-8,18,and19,while28.0%werepositiveforJUNB,44.0%forCXCR4,and48.0%forPD-L1.Conclusively,CXCR4,JUNB,andPD-L1werehighlyexpressedinCTCsfrommPCapatients.TheCXCR4proteinexpressionwasassociatedwithpoorerPFS,whilePD-L1wascorrelatedwithdecreasedOS,providingnewbiomarkerswithpotentialclinicalrelevance.Fullarticle(ThisarticlebelongstotheSpecialIssueCancer-RelatedSignalingCascades:CurrentKnowledgeandPotentialTherapeuticTargets)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,28KiB)15pes,2022KiB OpenAccessSystematicReviewInconsistentMethodsUsedtoSetAirwayPressureReleaseVentilationinAcuteRespiratoryDistressSyndrome:ASystematicReviewandMeta-RegressionAnalysisbyMarkR.Lutz,JacobCharlamb,JoshuaR.Kenna,AbigailSmith,StephenJ.Glatt,JoaquinD.Araos,PennyL.Andrews,NaderM.Habashi,GaryF.NiemanandAuyonJ.GhoshJ.Clin.Med.2024,13(9),2690;doi.org/10.3390/jcm(registering DOI)-03May2024AbstractAirwaypressurereleaseventilation(APRV)isaprotectivemechanicalventilationmodeforpatientswithacuterespiratorydistresssyndrome(ARDS)thattheoreticallymayreduceventilator-inducedlunginjury(VILI)andARDS-relatedmortality.However,thereisnostandardmethodtosetandadjusttheAPRVmode[...]Readmore.Airwaypressurereleaseventilation(APRV)isaprotectivemechanicalventilationmodeforpatientswithacuterespiratorydistresssyndrome(ARDS)thattheoreticallymayreduceventilator-inducedlunginjury(VILI)andARDS-relatedmortality.However,thereisnostandardmethodtosetandadjusttheAPRVmodeshowntobeoptimal.Therefore,weperformedameta-regressionanalysistoevaluatehowthefourindividualAPRVsettingsimpactedtheoutcomeinthesepatients.Methods:StudiesinvestigatingtheuseoftheAPRVmodeforARDSpatientsweresearchedfromelectronicdatabases.Wetestedindividualsettings,including(1)highairwaypressure(PHigh);(2)lowairwaypressure(PLow);(3)timeathighairwaypressure(THigh);and(4)timeatlowpressure(TLow)forassociationwithPaO2/FiO2ratioandICUlengthofstay.Results:TherewasnosignificantdifferenceinPaO2/FiO2ratiobetweenthegroupsinanyofthefoursettings(PHighdifference−12.0[95%CI−100.4,86.4];PLowdifference54.3[95%CI−52.6,161.1];TLowdifference−27.19[95%CI−127.0,72.6];THighdifference−51.4[95%CI−170.3,67.5]).Therewashighheterogeneityacrossallparameters(PhHghI2=99.46%,PLowI2=99.16%,TLowI2=99.31%,THighI2=99.29%).Conclusions:NoneofthefourindividualAPRVsettingsindependentlywereassociatedwithdifferencesinoutcome.Aholisticapproach,analyzingallsettingsincombination,mayimproveAPRVefficacysinceitisknownthatsmalldifferencesinventilatorsettingscansignificantlyaltermortality.FutureclinicaltrialsshouldsetandadjustAPRVbasedonthebestcurrentscientificevidenceailable.Fullarticle(ThisarticlebelongstotheTopicAcuteRespiratoryDistressSyndrome(ARDS):PersonalizedTherapiesandBeyond)9658;9660;ShowFiguresFigure1Figure2---Figure2Cont.---Figure3---Figure3Cont.attachmentSupplementarymaterial:SupplementaryFile1(ZIP,518KiB)18pes,3258KiB OpenAccessArticleHyperspectralandFluorescenceImingApproachesforNondestructiveDetectionofRiceChlorophyllbyJuZhou,FeiyiLi,XinwuWang,HengYin,WenjingZhang,JiaoyangDuandHaiboPuPlants2024,13(9),1270;doi.org/10.3390/plants(registering DOI)-03May2024AbstractEstimatingandmonitoringchlorophyllcontentisacriticalstepincropspectralimeanalysis.Thequick,non-destructiveassessmentofchlorophyllcontentinriceleescanoptimizenitrogenfertilization,benefittheenvironmentandeconomy,andimprovericeproductionmanementandquality.Inthisresearch,[...]Readmore.Estimatingandmonitoringchlorophyllcontentisacriticalstepincropspectralimeanalysis.Thequick,non-destructiveassessmentofchlorophyllcontentinriceleescanoptimizenitrogenfertilization,benefittheenvironmentandeconomy,andimprovericeproductionmanementandquality.Inthisresearch,spectralanalysisofriceleesisperformedusinghyperspectralandfluorescencespectroscopyforthedetectionofchlorophyllcontentinricelees.ThisstudygeneratedninetyexperimentalspectraldatasetsbycollectingriceleafsamplesfromafarminSichuanProvince,China.Byimplementingafeatureextractionalgorithm,thisstudycompressesredundantspectralbandsandsubsequentlyconstructsmachinelearningmodelstoreveallatentcorrelationsamongtheextractedfeatures.Thepredictioncapabilitiesofsixfeatureextractionmethodsandfourmachinelearningalgorithmsintwotypesofspectraldataareexamined,andanaccuratemethodofpredictingchlorophyllconcentrationinriceleeswasdevised.TheIVSO-IVISSA(IterativelyVariableSubsetOptimization–IntervalVariableIterativeSpaceShrinkeApproach)quadraticfeaturecombinationapproach,basedonfluorescencespectrumdata,hasthebestpredictionperformanceamongtheCNN+LSTM(ConvolutionalNeuralNetworkLongShort-TermMemory)algorithms,withcorrespondingRMSE-Train(RootMeanSquaredError),RMSE-Test,andRPD(Ratioofstandarddeviationofthevalidationsettostandarderrorofprediction)indexesof0.26,0.29,and2.64,respectively.Wedemonstratedinthisstudythathyperspectralandfluorescencespectroscopy,whenanalyzedwithfeatureextractionandmachinelearningmethods,provideanewenueforrapidandnon-destructivecrophealthmonitoring,whichiscriticaltotheadvancementofsmartandprecisionriculture.Fullarticle(ThisarticlebelongstotheSpecialIssueApplicationsofSpectralTechniquesinPlantPhysiology)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure517pes,1574KiB OpenAccessReviewImpactofTransgenerationalNutritiononNonalcoholicFattyLiverDiseaseDevelopment:InterplaybetweenGutMicrobiota,EpigeneticsandImmunitybyHong-TaiTzengandWei-ChiaLeeNutrients2024,16(9),1388;doi.org/10.3390/nu(registering DOI)-03May2024AbstractNonalcoholicfattyliverdisease(NAFLD)hasemergedasthemostprevalentpediatricliverdisorder,primarilyattributedtodietaryshiftsinrecentyears.NAFLDischaracterizedbytheaccumulationoflipidspeciesinhepatocytes,leadingtoliverinflammationthatcanprogresstosteatohepatitis,fibrosis,[...]Readmore.Nonalcoholicfattyliverdisease(NAFLD)hasemergedasthemostprevalentpediatricliverdisorder,primarilyattributedtodietaryshiftsinrecentyears.NAFLDischaracterizedbytheaccumulationoflipidspeciesinhepatocytes,leadingtoliverinflammationthatcanprogresstosteatohepatitis,fibrosis,andcirrhosis.RiskfactorscontributingtoNAFLDencompassgeneticvariationsandmetabolicdisorderssuchasobesity,diabetes,andinsulinresistance.Moreover,transgenerationalinfluences,resultinginanimbalanceofgutmicrobialcomposition,epigeneticmodifications,anddysregulatedhepaticimmuneresponsesinoffspring,playapivotalroleinpediatricNAFLDdevelopment.Maternalnutritionshapestheprofileofmicrobiota-derivedmetabolitesinoffspring,exertingsignificantinfluenceonimmunesystemregulationandthedevelopmentofmetabolicsyndromeinoffspring.Inthisreview,wesummarizerecentevidenceelucidatingtheintricateinterplaybetweengutmicrobiota,epigenetics,andimmunityinfetusesexposedtomaternalnutrition,anditsimpactontheonsetofNAFLDinoffspring.Furthermore,potentialtherapeuticstrategiestargetingthisnetworkarealsodiscussed.Fullarticle(ThisarticlebelongstotheSpecialIssueMaternalNutritionalIntakeandChildHealth)9658;9660;ShowFiguresFigure1MoreArticles...OpenAccessJournalsAcousticsActaMicrobiologicaHellenica(AMH)ActuatorsAdministrativeSciencesAdolescentsAdvancesinRespiratoryMedicine(ARM)AerobiologyAerospacericultureriEngineeringrochemicalsronomyAIAirAlgorithmsAllergiesAlloysAnalyticaAnalyticsAnatomiaAnesthesiaResearchAnimalsAntibioticsAntibodiesAntioxidantsAppliedBiosciencesAppliedMechanicsAppliedMicrobiologyAppliedNanoAppliedSciencesAppliedSystemInnovation(ASI)AppliedChemAppliedMathAquacultureJournalArchitectureArthropodaArtsAstronomyAtmosphereAtomsAudiologyResearchAutomationAxiomsBacteriaBatteriesBehioralSciencesBeveresBigDataandCognitiveComputing(BDCC)BioChemBioengineeringBiologicsBiologyBiologyandLifeSciencesForumBiomassBiomechanicsBioMedBiomedicinesBioMedInformaticsBiomimeticsBiomoleculesBiophysicaBiosensorsBioTechBirdsBlockchainsBrainSciencesBuildingsBusinessesCCancersCardiogeneticsCatalystsCellsCeramicsChallengesChemEngineeringChemistryChemistryProceedingsChemosensorsChildrenChipsCivilEngCleanTechnologies(CleanTechnol.)ClimateClinicalandTranslationalNeuroscience(CTN)ClinicsandPracticeClocks&SleepCoastsCoatingsColloidsandInterfacesColorantsCommoditiesComplicationsCompoundsComputationComputerSciences&MathematicsForumComputersCondensedMatterConservationConstructionMaterialsCorrosionandMaterialsDegradation(CMD)CosmeticsCOVIDCropsCryptographyCrystalsCurrentIssuesinMolecularBiology(CIMB)CurrentOncologyDairyDataDentistryJournalDermatoDermatopathologyDesignsDiabetologyDinosticsDieteticsDigitalDisabilitiesDiseasesDiversityDNADronesDrugsandDrugCandidates(DDC)DynamicsEarthEcologiesEconometricsEconomiesEducationSciencesElectricityElectrochemElectronicMaterialsElectronicsEmergencyCareandMedicineEncyclopediaEndocrinesEnergiesEngEngineeringProceedingsEntropyEnvironmentalSciencesProceedingsEnvironmentsEpidemiologiaEpigenomesE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